Ndehupi hukama pakati pekuora mwoyo muzera repakati uye Tau deposition?

Maererano nekuongorora kutsva kwakaitwa nevatsvakurudzi veUT Health San Antonio uye masangano ayo anofambidzana nawo, vanhu vepakati-kati vane zviratidzo zvekuora mwoyo vanotakura puroteni inonzi APOE.Shanduko mu epsilon 4 Inogona kunge yakanyanya kuburitsa tau buildup munzvimbo dzehuropi dzinodzora mafungiro uye ndangariro.

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Zvakawanikwa zvakaburitswa muna Chikumi 2021 kudhindwa kweChinyorwa cheAlzheimer's Disease.Chidzidzo chacho chaive chakavakirwa pakuora mwoyo kuongororwa uye positron emission tomography (PET) imaging ye201 vatori vechikamu mune multigenerational Framingham Heart Study.Avhareji yezera revatori vechikamu yaive 53.

Mikana yekuwana chirwere makumi emakore isati yaonekwa

PET inowanzoitwa kune vanhu vakuru, saka Framingham KUDZIDZA paPET muzera repakati yakasiyana, akadaro Mitzi M. Gonzales, munyori mukuru wekudzidza uye neuropsychologist paGlenn Biggs Institute for Alzheimer's disease uye Neurodegenerative Diseases, iyo chikamu che Yunivhesiti yeTexas Health Center kuSAN Antonio.

"Izvi zvinotipa mukana unofadza wekudzidza vanhu vepakati uye kunzwisisa zvinhu zvingave zvakabatana nekuunganidza mapuroteni muvanhu vane ruzivo rwekuziva," akadaro Dr. Gonzales."Kana vanhu ava vakaenderera mberi nekuita dementia, chidzidzo ichi chinoburitsa mikana iyi makumi emakore vasati vaongororwa."

Izvo hazvina chekuita ne beta-amyloid

Beta-amyloid (Aβ) neTau mapuroteni anoungana muuropi hwevanhu vane chirwere cheAlzheimer uye anowanzo wedzera zvinyoro nezera zvakare.Chidzidzo chacho hachina kushamwaridzana pakati pezviratidzo zvekuora mwoyo uye kuora mwoyo uye beta-amyloid.Yaingobatanidzwa naTau, uye chete nevatakuri veAPOE ε4 mutation.Chinenge chikamu chechina chevarwere ve201 (47) vakatakura ε4 gene nekuti vaive neine imwe ε4 allele.

Kutakura kopi imwe chete yejini yeAPOEε4 kunowedzera njodzi yechirwere cheAlzheimer kaviri kana katatu, asi vamwe vanhu vanotakura musiyano wejeni iri vanogona kurarama kusvika kuma80s kana 90s vasina kumbova nechirwere ichi."Zvakakosha kuyeuka kuti kana munhu akaonekwa seakatakura APOE ε4 hazvirevi kuti achava nedementia mune ramangwana," akadaro Dr. Gonzales.Zvinongoreva kuti matambudziko akakwira. "

Kuora mwoyo zviratidzo (kuora mwoyo kana zviratidzo zvakanyanya zvakakwana kuti zvisangane nechikumbaridzo ichi chekuongorora) zvakaongororwa panguva yePET imaging uye makore masere asati ashandisa Epidemiological Research Center Depression Scale.Zviratidzo zvekuora mwoyo uye kushamwaridzana pakati pekuora mwoyo uye PET migumisiro panguva mbiri dzakaongororwa, dzakagadziriswa kwezera uye zvepabonde.

Emotional uye cognitive nzvimbo

Chidzidzo chacho chakaratidza kushamwaridzana pakati pezviratidzo zvekuora mwoyo uye kuwedzera kwetau munzvimbo mbiri dzeuropi, entorhinal cortex uye amygdala."Izvi masangano hazvirevi kuti tau kuunganidza kunokonzera kuora mwoyo zviratidzo kana zvakasiyana," Dr. Gonzales akadaro."Isu takangoona zvinhu zviviri izvi mu ε4 vatakuri."

Akacherekedza kuti entorhinal cortex yakakosha mukubatanidza ndangariro uye inoita kunge iri nharaunda iyo protein deposition inoitika nekukurumidza.Zvichakadaro, amygdala inofungidzirwa kuti ndiyo nzvimbo yepfungwa yeuropi.

"Zvidzidzo zvenguva refu zvinodiwa kuti uwedzere kunzwisisa zviri kuitika, asi zvinonakidza kufunga nezvehutano hwekliniki yezvatinowana maererano nekugadzirisa mafungiro uye mafungiro," akadaro Dr. Gonzales.


Nguva yekutumira: 26-08-21